Can I run Gemma 4 12B on an RTX 4080 Super 16GB?

Yes: Gemma 4 12B needs about 8.98 GB at Q4_K_M with 32K tokens of context, which fits the RTX 4080 Super 16GB with 7.02 GB to spare. At 32K the RTX 4080 Super holds up to Q8_0 (14.6 GB), and Q4_K_M runs up to 256K (full) tokens.

Yes Q4_K_M with 32K tokens of context

Q4_K_M, 32K
8.98 GB
RTX 4080 Super
16 GB, 736 GB/s
To spare
7.02 GB
Tokens/s
46–65 tokens/s

At Q4_K_M with 32K tokens of context it writes about 46–65 tokens/s for one request on an RTX 4080 Super 16GB.

Best precision for Gemma 4 12B on an RTX 4080 Super 16GB

The most precise setting that leaves at least 0.5 GB free; one that fits with less is marked tight.

ContextBest fitMemoryFreeTokens/s
8K Q8_0 14.2 GB 1.83 GB 29–41
32K Q8_0 14.6 GB 1.42 GB 28–39
128K FP8 15.5 GB 545 MB 27–37
256K (full) Q6_K 15.5 GB 550 MB 27–37

Gemma 4 12B on the RTX 4080 Super as the context fills

One request, FP16 KV cache, 0.5 GB plus 10% overhead; a minus sign is memory missing, and tight is less than 0.5 GB free.

Context Q4_K_MFreeTokens/sQ8_0FreeTokens/s
4K 8.50 GB 7.50 GB 48–68 14.1 GB 1.90 GB 29–41
8K 8.57 GB 7.43 GB 48–68 14.2 GB 1.83 GB 29–41
16K 8.70 GB 7.30 GB 47–67 14.3 GB 1.69 GB 29–40
32K 8.98 GB 7.02 GB 46–65 14.6 GB 1.42 GB 28–39
64K 9.53 GB 6.47 GB 43–61 15.1 GB 887 MB 27–38
128K 10.6 GB 5.37 GB 39–54 16.2 GB −239 MB —
256K (full) 12.8 GB 3.17 GB 32–45 18.4 GB −2.43 GB —

Gemma 4 12B on more than one RTX 4080 Super

CardsBest at 32KTokens/sQ4_K_M longestQ4_K_M tokens/s
2× (32 GB) BF16 29–42 256K (full) 73–114
4× (64 GB) BF16 53–79 256K (full) 116–198

Tensor parallel with the combined bandwidth, as in vLLM; llama.cpp splits layers by default and runs at about one card's speed.

Other options

Run Gemma 4 12B on the RTX 4080 Super with llama-server

llama-server -hf unsloth/gemma-4-12b-it-GGUF:Q4_K_M -c 262144 -np 1

gemma-4-12b-it-Q4_K_M.gguf, 7.1 GB, from unsloth/gemma-4-12b-it-GGUF (checked 2026-09-29). At -c 262144 on the RTX 4080 Super: 12.8 GB of 16 GB, 3.17 GB free. -np 1: one slot, one sliding window.

Questions

Can I run Gemma 4 12B on an RTX 4080 Super 16GB?

Yes: Gemma 4 12B needs about 8.98 GB at Q4_K_M with 32K tokens of context, which fits the RTX 4080 Super 16GB with 7.02 GB to spare. At 32K the RTX 4080 Super holds up to Q8_0 (14.6 GB), and Q4_K_M runs up to 256K (full) tokens.

How fast is Gemma 4 12B on an RTX 4080 Super 16GB?

At Q4_K_M with 32K tokens of context it writes about 46–65 tokens/s for one request on an RTX 4080 Super 16GB.

What does a second RTX 4080 Super 16GB change for Gemma 4 12B?

Two RTX 4080 Super 16GB cards (32 GB in one tensor-parallel group) hold Gemma 4 12B at BF16 with 32K, and Q4_K_M up to 256K (full) tokens, at about 73–114 tokens/s.

Try other settings in the VRAM calculator or the speed calculator. See also Gemma 4 12B VRAM requirements, what LLMs an RTX 4080 Super 16GB can run and every pair, or detect your own GPU. Model data checked .